Bacterial Cellulose–Polyvinyl Alcohol Based Complex Composites for Controlled Drug Release

Drug-loaded mono- and multilayer composite membranes were prepared. The composites, based on nano-fibrillated bacterial cellulose, nano-powdered polyvinyl alcohol, all biocompatible biodegradable, characterized in terms of basic factors related to drug diffusivity mass transfer: swelling ability, water solubility, vapor permeability. Tetracycline hydrochloride was used this case as model. Drug release evaluated an aqueous environment for two concentration levels the antibiotic, mathematical modeling applied fit experimental data. influenced by a membranes’ structure, layers’ composition, thickness. Bacterial cellulose nanofibrils proved be key factor achieving suitable profiles. Thus, sustained antibiotic delivery obtained several days composites. composites stability antibacterial efficiency before after TC-HCl continuous days.